CD59 Recombinant Protein
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| Amount : | 10 µg |
| Purification : | Greater than 85% as determined by SDS-PAGE. |
| Content : | The CD59 solution contains 20mM Tris-HCl buffer (pH 8.0), 0.15M NaCl, 1mM DTT and 10% glycerol. |
| Storage condition : | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| AA sequence : | MGSSHHHHHH SSGLVPRGSH MGSLQCYNCP NPTADCKTAV NCSSDFDACL ITKAGLQVYN KCWKFEHCNF NDVTTRLREN ELTYYCCKKD LCNFNEQLEN. |
| Alternative Name : | CD59 Molecule Complement Regulatory Protein, CD59 Antigen P18-20, CD59 Glycoprotein, Surface Anitgen Recognized By Monoclonal Antibody 16.3A5, Membrane Attack Complex (MAC) Inhibition Factor, Lymphocytic Antigen CD59/MEM43, Human Leukocyte Antigen MI |
Source : Escherichia Coli.
CD59 Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 100 amino acids (26-102) and having a molecular mass of 11.3kDa.CD59 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
CD59 is a cell surface glycoprotein which regulates complement-mediated cell lysis, and it is involved in lymphocyte signal transduction. CD59 is an effective inhibitor of the complement membrane attack complex, whereby it binds complement C8 and/or C9 during the compilation of this complex, thus inhibiting the incorporation of multiple copies of C9 into the complex, which is essential for osmolytic pore formation. In addition, CD59 has a role in signal transduction pathways in the activation of T cells. CD59 gene mutations cause CD59 deficiency, a disease resulting in hemolytic anemia and thrombosis, and which causes cerebral infarction.
For Research Use Only. Not for use in diagnostic/therapeutics procedures.
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