Canine PD-1 Protein, mFc Tag
Figure 1. Canine PD-1 Protein, mFc Tag on SDS-PAGE under reducing condition.
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| Amount : | 100 µg |
| Purification : | The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining. |
| Content : | Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8% trehalose is added as protectants before lyophilization. |
| Storage condition : | Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature. |
| Uniprot ID : | NP_001301026.1 |
| Alternative Name : | CD279, PD-1, PD1, SLEB2, hPD-1, hPD-l, hSLE1 |
Description :Recombinant Canine PD-1 protein with C-terminal mouse Fc tag
Background : Programmed cell death protein 1 (PDCD1) is an immune-inhibitory receptor expressed in activated T cells; it is involved in the regulation of T-cell functions, including those of effector CD8 T cells. In addition, this protein can also promote the differentiation of CD4 T cells into T regulatory cells. PDCD1 is expressed in many types of tumors including melanomas, and has demonstrated to play a role in anti-tumor immunity. Moreover, this protein has been shown to be involved in safeguarding against autoimmunity, however, it can also contribute to the inhibition of effective anti-tumor and anti-microbial immunity.
Molecular Characterization: mass of 42.4 kDa after removal of the signal peptide. The apparent molecular mass of dPD-1-mFc is approximately 55-70 kDa due to glycosylation.
Tag :C-Mouse Fc tag
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