APC Conjugated Anti-Human CD270 (Clone: CW10)
Figure 1: Separation of SK-MEL-30 cells stained using anti-human CD270 (CW10) APC antibody (10 μl reagent per million cells in 100 μl of cell suspension, red-filled) from SK-MEL-30 cells stained using mouse IgG1 isotype control (MOPC-21) APC antibody (concentration in sample 5 μg/ml, same as CD270 APC concentration, black-dashed) in flow cytometry analysis (surface staining) of SK-MEL-30 cell suspension.
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| Amount : | 100 tests |
| Isotype : | Mouse IgG1 kappa |
| Purification : | Purified antibody is conjugated with activated allophycocyanin (APC) under optimum conditions and unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography. |
| Content : | Formulation: Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide |
| Storage condition : | Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze. |
CD270 is a type I transmembrane protein of the TNFR superfamily, which is expressed on resting T cells, monocytes, and immature dendritic cells. Its ligands, CD258 and CD272, differ in effect on CD270 signaling. Whereas binding to CD258 provides a costimulatory signal, binding to CD272 gives to the cell an inhibitory signal. CD270 also is recognized by herpes simplex glycoprotein D. CD258-CD270 interaction and signaling is implicated in macrophage-derived foam cell-mediated development of atherosclerotic lesions.
Specificity: The mouse monoclonal antibody CW10 recognizes an extracellular epitope on CD270, a type I transmembrane protein expressed on resting T cells, monocytes, and immature dendritic cells.
For Research Use Only. Not for use in diagnostic/therapeutics procedures.
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