Anti-Ubinuclein 1 Monoclonal Antibody (Clone:UBN1-02)
Figure 1: Western blotting analysis of ubinuclein in nuclear fraction of HeLa cells. The monoclonal antibody UBN1-01 (. Lane A, B) detects ubinuclein 1 (165 kDa) and an 180 kDa protein - presumable ubinuclein 2. The antibody UBN1-02 (. Lane C, D) detects ubinuclein 1. Antibody dilution: A, C - 1 µg/ml; B, D - 5 µg/ml.
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| Format : | Purified |
| Amount : | 0.1 mg |
| Isotype : | Mouse IgG |
| Purification : | Purified by protein-A affinity chromatography |
| Storage condition : | Store at 2-8°C. Do not freeze. |
Ubinuclein 1 (UBN1) is a ubiquitously expressed evolutionarily conserved protein which binds to proliferation-promoting genes that are repressed by formation of senescence-associated heterochromatin foci (SAHF). Ubinuclein 1 associates with various transcription factors and with histone methyltransferase activity, is indispensable for SAHF formation and appears to be a regulator of senescence. Although in most cells ubinuclein is localized to the nucleus, in cells forming tight junctions it is recruited to the cell adhesion complexes, dependently on the cell density.
Western Blotting Recommended dilution: 1-5 µg/ml
Positive control: HeLa cell line
For Research Use Only. Not for use in diagnostic/therapeutics procedures.
| Subcellular location: | Nucleus, Nucleus, Cell junction |
| Tissue Specificity: | Ubiquitous. Also expressed in numerous tumors and cancer cell lines. |
| BioGrid: | 118934. 38 interactions. |
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