Anti-Tyrosinase-Related Protein-1 (TYRP-1) (Melanoma Marker) Recombinant Rabbit Monoclonal Antibody (Clone:TYRP1/2340R)
Figure 1: Formalin-fixed, paraffin-embedded human Basal Cell Carcinoma stained with TYRP1 Recombinant Rabbit Monoclonal Antibody (TYRP1/2340R).
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Shipping Info:
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| Format : | Purified |
| Amount : | 100 µg |
| Isotype : | Rabbit IgG |
| Purification : | Protein A/G |
| Content : | 200µg/ml of recombinant MAb purified by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml. |
| Storage condition : | Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. |
| Gene : | TYRP1 |
| Gene ID : | 7306 |
| Uniprot ID : | P17643 |
| Alternative Name : | 5, 6 dihydroxyindole 2 carboxylic acid oxidase, 6-dihydroxyindole-2-carboxylic acid oxidase, Associated with iris pigmentation, CAS2, Catalase B (CATB), DHICA oxidase, Glycoprotein75 (GP75), Melanoma antigen gp75, Tyrosinase-related protein 1 (TYRP1), TYRRP |
| Immunogen Information : | Recombinant fragment of human TYRP1 protein (around aa 257-377) (exact sequence is proprietary) |
It reacts with a 75kDa melanocyte-specific gene product, identified as Tyrosinase-related protein-1 (TRP-1). It is involved in melanin synthesis. TRP1 is present on the melanosomal membranes of melanoma, normal melanocytes and nevi. Recent evidence sµggests that TRP-1 is involved in maintaining stability of tyrosinase protein and modulating its catalytic activity. TRP-1 is also involved in maintenance of melanosome ultrastructure and affects melanocyte proliferation and cell death.
ELISA (Use Ab at 2-4µg/ml for coating) (Order Ab without BSA); Immunohistochemistry (Formalin-fixed) (1-2µg/ml for 30 minutes at RT)(Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes);
For Research Use Only. Not for use in diagnostic/therapeutics procedures.
| Subcellular location: | Melanosome membrane, Melanosome |
| Post transnational modification: | Glycosylated. |
| Tissue Specificity: | Pigment cells. |
| BioGrid: | 113156. 7 interactions. |
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