Anti-TRIM / TRAT1 Monoclonal Antibody (Clone:TRIM-04)
Figure 1: Western blot of human Jurkat T cell line lysate (1% laurylmaltoside); non-reduced sample, immunostained by mAb TRIM-04 and goat anti-mouse IgG (H+L)-HRP conjugate.
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Shipping Info:
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| Format : | Purified |
| Amount : | 0.1 mg |
| Isotype : | Mouse IgG2a |
| Purification : | Purified by protein-A affinity chromatography |
| Storage condition : | Store at 2-8°C. Do not freeze. |
TRIM (T cell receptor-interacting molecule), also known as TRAT1 (T cell receptor associated transmembrane adaptor 1) is a 30 kDa protein expressed by T cells as a cystein-linked homodimer. It associates with TCR-CD3-zeta-chain complex and becomes phosphorylated by Src-family kinases. TRIM is potentially involved in negative regulation of TCR-mediated signaling, but its role remains unclear.
| Subcellular location: | Cell membrane |
| Post transnational modification: | Phosphorylated on tyrosines by LCK or FYN upon TCR activation. |
| Tissue Specificity: | Strongly expressed in thymus, and to a lesser extent in spleen, lymph node and peripheral blood lymphocytes. Present in T-cells and NK cells, but not B-cells (at protein level). |
| BioGrid: | 119154. 16 interactions. |
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