Anti-TPX2 Monoclonal Antibody (Clone:TPX2-01)
Figure 1: Western blotting analysis of TPX2 using monoclonal antibody TPX2-01 in A) human cell lines, B) murine (P19, NIH 3T3, Neuro-2a) and rat (RBL-2H3, L6) cell lines.
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| Format : | Purified |
| Amount : | 0.1 mg |
| Isotype : | Mouse IgG1 |
| Purification : | Purified from hybridoma culture supernatant by protein-A affinity chromatography. |
| Storage condition : | Store at 2-8°C. Do not freeze. |
TPX2 is a microtubule-associated protein, which is a critical regulator of mitosis. At the beginning of mitosis, TPX2 is released and plays a significant role in mitotic spindle formation and subsequent proper segregation of chromosomes during cell division. After completion of mitosis the TPX2 protein disappears, but has also role in DNA damage response. Its overexpression has been demonstrated in many types of carcinomas. TPX2 belongs to the markers of worse tumor prognosis. On the other hand, down-regulation of TPX2 can inhibit cancer cell proliferation, migration and invasion.
Immunoprecipitation Western Blotting Immunohistochemistry Immunocytochemistry
For Research Use Only. Not for use in diagnostic/therapeutics procedures.
| Subcellular location: | Nucleus, Cytoplasm, Cytoplasm |
| Tissue Specificity: | Expressed in lung carcinoma cell lines but not in normal lung tissues. |
| BioGrid: | 116624. 42 interactions. |
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