anti-TNF-Alpha (mouse), mAb (blocking) (V1q) (preservative free)
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| Amount : | 100 µg |
| Isotype : | Rat IgD |
| Purification : | >=95% (SDS-PAGE) |
| Content : | Concentration: 1mg/ml Formulation: Liquid. In PBS. |
| Storage condition : | Stable for at least 1 year after receipt when stored at -20°C. |
| Alternative Name : | Tumor Necrosis Factor Ligand Superfamily Member 2; TNFSF2; Cachectin |
| Immunogen Information : | Cytotoxin purified from ConA induced T cell clone 29. |
Purified from concentrated hybridoma tissue culture supernatant.It recognizes and reacts both natural and recombinant mouse TNF-alpha. It cross-reacts with recombinant human TNF-alpha in an ELISA binding assay (blocking not tested). It does not cross-react with TNF-beta (Lymphotoxin-Alpha). Tumor necrosis factor (TNF, cachexin or cachectin and formerly known as tumor necrosis factor-alpha) is a cytokine involved in systemic inflammation and metabolism and is a member of a group of cytokines that stimulate the acute phase reaction. It causes tumor necrosis in vivo and shows also cytolytic activity against tumors. Signal transduction occurs via two types of TNF-receptors, the TNF-receptors 1 and 2. The receptor TNF-R1 is activated by both the membrane-bound and soluble trimeric forms of TNF-alpha, whereas the receptor TNF-R2 only responds to the membrane-bound form of TNF-alpha. The monoclonal antibody V1q recognizes endogenous mouse TNF-alpha.
Endotoxin Content: <0.01EU/ µg purified protein (LAL test). Functional Application: Inhibition of mouse TNF-alpha function in vivo (in mice). 20µg of antibody/mouse is sufficient to block the activity of endogenous mouse TNF-alpha. Flow Cytometry: (1:200-1:1'000)
For Research Use Only. Not for use in diagnostic/therapeutics procedures.
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