Anti-TIM3 Monoclonal Antibody (Clone:IHC003)-Ready to Use

Product code: 44-1092

Clone name : IHC003
Clonality : Monoclonal
Application : IHC
Reactivity : Human

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Size
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7 ml
$657.00 

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Amount : 7 ml
Isotype : Mouse IgG1
Purification : Protein A/G Chromatography
Content : Tris Buffer, pH 7.3 - 7.7, with 1% BSA and <0.1% Sodium Azide
Storage condition : Store at 2°C - 8°C. Do not freeze.
Gene : HAVCR2
Gene ID : 84868
Uniprot ID : Q8TDQ0
Alternative Name : HAVCR2, TIM3, TIMD3
Immunogen Information : Recombinant Human TIM3

"T-cell Immunoglobulin and Mucin-Domain-Containing Molecule-3 (TIM3) is present on T-helper type 1 lymphocytes and other immune cells including dendritic cells and natural killer cells. TIM3 is overexpressed in CD4+ tumor-infiltrating lymphocytes, including those with non-small cell lung cancer associated with poor prognoses. TIM3 has recently emerged as a potential target for cancer immunotherapy."

This product is available in ready to use format, hence no dilution is required.

For Research Use Only. Not for use in diagnostic/therapeutics procedures.

Subcellular location: Membrane, Cell junction
Post transnational modification: Phosphorylated on tyrosine residues; modestly increased after TCR/CD28 stimulation. Can be phosphorylated in the cytoplasmatic domain by FYN (By similarity). Phosphorylation at Tyr-265 is increased by stimulation with ligand LGALS9.
Tissue Specificity: Expressed in T-helper type 1 (Th1) lymphocytes. Expressed on regulatory T (Treg) cells after TCR stimulation. Expressed in dendritic cells and natural killer (NK) cells. Expressed in epithelial tissues. Expression is increased on CD4+ and CD8+ T-cells in chronic hepatitis C virus (HCV) infection. In progressive HIV-1 infection, expression is up-regulated on HIV-1-specific CD8 T-cells.
BioGrid: 124313. 72 interactions.
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