Anti-TFG Monoclonal Antibody (Clone:TFG-03)
Figure 1: Western blotting analysis of TFG in Jurkat cell lysate using anti-TFG (TFG-03) purified.
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| Format : | Purified |
| Amount : | 0.1 mg |
| Isotype : | Mouse IgG2b |
| Purification : | Purified by protein-A affinity chromatography |
| Storage condition : | Store at 2-8°C. Do not freeze. |
TFG (TRK-fused gene protein) is a regulatory protein with not fully understood function. Its defects are associated with various carcinomas, such as e.g. melanoma, thyroid papillary carcinoma, or glioma. TFG structure (multiple protein interaction motifs) indicated it can be an adaptor protein. It has been demonstrated TFG interacts with proteins modulating the NFkappaB pathway (TANK and NEMO). TNG enhances the effect of TNFalpha, TANK, TRAF2 and TRAF6 in inducing NFkappaB activity.
| Subcellular location: | Endoplasmic reticulum |
| Tissue Specificity: | Ubiquitous. |
| BioGrid: | 115624. 132 interactions. |
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