Anti-TCR beta Monoclonal Antibody (Clone:H57-597)(Discontinued)

The antigen-specific T cell receptor (TCR) is composed of either alpha and beta subunit, or gamma and delta subunit. Majority of T cells present in the blood, lymph and secondary lymphoid organs express TCR alpha/beta heterodimers, whereas the T cells expressing TCR gamma/delta heterodimers are localized mainly in epithelial tissues and at the sites of infection. The subunits of TCR heterodimers are covalently bonded and in the endoplasmic reticulum they associate with CD3 subunits to form functional TCR-CD3 complex. Lack of expression of any of the chains is sufficient to stop cell surface expression.

Flow Cytometry Recommended dilution: 1-2 µg/ml per 1 million cells
Immunoprecipitation Recommended dilution: 1-2 µg / 100-500 µg of protein in 1 ml lysate
Immunohistochemistry Immunohistochemistry (frozen sections) Immunocytochemistry Functional Application In vitro T cell stimulation; In vivo T cell depletion

For Research Use Only. Not for use in diagnostic/therapeutics procedures.

Subcellular location:	Cytoplasm, Nucleus
Post transnational modification:	Phosphorylation at Ser-1064 down-regulates lipid kinase activity.
BioGrid:	217006. 5 interactions.

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