Anti-TAp63 Purified
Figure 1: Western blotting analysis, confirming specificity of mouse monoclonal antibody TAp63-4.1 for TAp63 isoform of p63 protein. Cell lysates from particular transfectants of TAp63alpha, TAp63gamma, deltaNp63alpha, TAp73alpha, and deltaNp73alpha were analysed
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| Format : | Purified |
| Amount : | 0.1 mg |
| Purification : | Purified by protein-A affinity chromatography. |
| Content : | Storage Buffer: Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide |
| Storage condition : | Store at 2-8°C. Do not freeze. |
The p53 family of proteins includes three members, p53, p63, and p73. The protein p63 is encoded by TP63 gene, which gives rise to protein isoforms with different properties and functions due to the presence (TAp63) or absence (deltaNp63) of an N-terminal transactivation domain. Immunohistochemistry of p63 has a clinical relevance for certain tumor types, but investigations have been hampered by a lack of well characterized antibodies that are specific for p63, do not cross-react with the related p53 and p73 proteins, and allow for discrimination between p63 isoforms TAp63 and deltaNp63 with opposite functional properties.
Specificity :The mouse monoclonal antibody TAp63-4.1 recognizes TAp63; target epitope LSDPMW. This antibody does not bind to deltaNp63 isoform of p63.
Western blotting: Recommended dilution: 1 µg/ml
For Research Use Only. Not for use in diagnostic/therapeutics procedures.
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