Anti-Squamous Cell Carcinoma Antigen 1 Monoclonal Antibody(Clone: CPTC-SERPINB3-2)
Fig. 1: SDS-PAGE Analysis Purified SqCC Antigen 1 Mouse Monoclonal Antibody (CPTC-SERPINB3-2). Confirmation of Purity and Integrity of Antibody
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| Amount : | 100 µg |
| Isotype : | Mouse IgG1, kappa |
| Content : | 200 µg/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml. |
| Storage condition : | Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. |
| Gene : | SERPINB3 |
| Gene ID : | 6317 |
| Uniprot ID : | P29508 |
| Alternative Name : | HsT1196; Protein T4 A; Protein T4-A; SCC; SCCA-PD; SCCA1; SCCAPD; Serine (or cysteine) proteinase inhibitor clade B (ovalbumin) member 3; Serpin B3; SERPINB3; Squamous cell carcinoma antigen 1; T4 A; T4-A |
| Immunogen Information : | Recombinant human full-length SERPINB3 protein |
Metastasis of a primary tumor to a distant site is determined throµgh signaling cascades that break down interactions between the cell and extracellular matrix proteins. Among the proteins mediating metastasis are serine proteases, such as neutrophil elastase. Serpins are family of serine protease inhibitors, contain a stretch of peptide that mimics a true substrate for a corresponding serine protease. Serine proteases bind to this substrate mimic in a 1:1 stoichiometric fashion and become catalytically inactive. Aberrant expression of serpin family members can contribute to a number of conditions, including emphysema (-1 antitrypsin deficiency), fatal bleeding (elastase to Thrombin specificity) and thrombosis (antithrombin deficiency), and are indicators of cancer stage phenotypes (circulating levels of squamous cell carcinoma antigen, known as SCCA1, increase in advancing stages of some cervical, lung, esophageal and head and neck cancers). SCCA1 expression has been demonstrated to promote oncogenic transformation and epithelial-mesenchymal transition (EMT) in mammary epithelial cells, and its silencing in breast cancer cells has been shown to halt their proliferation.
Western Blot (1-2ug/ml);
For Research Use Only. Not for use in diagnostic/therapeutics procedures.
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