Anti-SOCS3 / Suppressor of cytokine signaling Monoclonal Antibody (Clone:SO1)
Figure 1: Western Blotting analysis (reducing conditions) of whole cell lysate of HeLa human cervix carcinoma cell line. Lane 1: immunostaining with Isotype mouse IgG2b control (PLRV219; ). Lane 2: immunostaining with anti-SOCS3 (SO1)
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| Format : | Purified |
| Amount : | 0.1 mg |
| Isotype : | Mouse IgG2b |
| Purification : | Purified by protein-A affinity chromatography |
| Storage condition : | Store at 2-8°C. Do not freeze. |
SOCS3 (suppressor of cytokine signaling 3), also known as CIS3 (cytokine-inducible SH2 protein 3) is a negative regulator of particular cytokine signaling pathways. SOCS3 is induced by a variety of cytokines and other stimuli, such as erythropoietin, leptin and lipopolysaccharides and inhibits tyrosinkinase activity of JAK kinases, or e.g. JNK phosphorylation. SOCS3 modulates cytokine-mediated and neoplastic-proliferative responses and is involved also in maintaining leukocytes in quiescent state until antigen stimulation.
Western Blotting Positive control: HeLa human cervix carcinoma cell line
For Research Use Only. Not for use in diagnostic/therapeutics procedures.
| Post transnational modification: | Phosphorylated on tyrosine residues after stimulation by the cytokines, IL-2, EPO or IGF1. |
| Tissue Specificity: | Widely expressed with high expression in heart, placenta, skeletal muscle, peripheral blood leukocytes, fetal and adult lung, and fetal liver and kidney. Lower levels in thymus. |
| BioGrid: | 114488. 78 interactions. |
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