Anti-SLP76 Polyclonal Antibody

Product code: 30-1283

Clonality : Polyclonal
Application : WB, IHC
Reactivity : Human

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0.1 mg
$433.00 

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Format : Purified
Amount : 0.1 mg
Isotype : Rabbit IgG
Purification : Purified from rabbit serum by precipitation methods
Storage condition : Store at 2-8°C. Do not freeze.
Gene : LCP2
Gene ID : 3937
Uniprot ID : Q13094
Alternative Name : LCP2
Immunogen Information : Bacterially expressed fusion protein representing amino acids 216-434 of human SLP76 with histidine tag
SLP76 (SH2 domain-containing leukocyte protein of 76 kDa) is a cytosolic adaptor protein which translocates to the plasma mambrane and is involved in multiple signaling pathways in T cells, mast cells, neutrophils and platelets; B cells express its analog SLP65/BLNK (B cell linker protein). SLP76 is phosphorylated by Syk-family and Tec-family tyrosine kinases and couples them to the phosphorylation and activation of PLC-gamma. Via Gads or Grb2, SLP76 also associates with LAT adaptor by involvement of SLP76 proline-rich region. The SH2 domain of SLP76 has been identified as the region involved in binding the serine/threonine kinase HPK1. HPK1 may act as both a positive and a negative regulator by promoting the Jnk-mitogen activated protein kinase (MAPK) pathway and inhibiting the pathway leading to AP-1 activation.

Immunohistochemistry Recommended dilution:10 µg/ml
Positive tissue: thymus

For Research Use Only. Not for use in diagnostic/therapeutics procedures.

Subcellular location: Cytoplasm
Post transnational modification: Phosphorylated after T-cell receptor activation by ZAP70, ITK and TXK, which leads to the up-regulation of Th1 preferred cytokine IL-2. SYK-dependent phosphorylation is required for recruitment of PI3K signaling components.
Tissue Specificity: Highly expressed in spleen, thymus and peripheral blood leukocytes. Highly expressed also in T-cell and monocytic cell lines, expressed at lower level in B-cell lines. Not detected in fibroblast or neuroblastoma cell lines.
BioGrid: 110129. 34 interactions.
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