Anti-SLP76 Monoclonal Antibody (Clone:SLP-76/03)
Figure 1: Western Blotting analysis (reducing conditions) of whole cell lysate using anti-SLP76 (SLP-76/03). Lane 1: HPB-ALL human peripheral blood T cell leukemia cell line. Lane 2: JURKAT human peripheral blood T cell leukemia cell line. Lane 3: RAMOS human Burkitt lymphoma cell line
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| Format : | Purified |
| Amount : | 0.1 mg |
| Isotype : | Mouse IgG2b |
| Purification : | Purified by protein-G affinity chromatography |
| Storage condition : | Store at 2-8°C. Do not freeze. |
SLP76 (SH2 domain-containing leukocyte protein of 76 kDa) is a cytosolic adaptor protein which translocates to the plasma mambrane and is involved in multiple signaling pathways in T cells, mast cells, neutrophils and platelets; B cells express its analog SLP65/BLNK (B cell linker protein). SLP76 is phosphorylated by Syk-family and Tec-family tyrosine kinases and couples them to the phosphorylation and activation of PLC-gamma. Via Gads or Grb2, SLP76 also associates with LAT adaptor by involvement of SLP76 proline-rich region. The SH2 domain of SLP76 has been identified as the region involved in binding the serine/threonine kinase HPK1. HPK1 may act as both a positive and a negative regulator by promoting the Jnk-mitogen activated protein kinase (MAPK) pathway and inhibiting the pathway leading to AP-1 activation.
| Subcellular location: | Cytoplasm |
| Post transnational modification: | Phosphorylated after T-cell receptor activation by ZAP70, ITK and TXK, which leads to the up-regulation of Th1 preferred cytokine IL-2. SYK-dependent phosphorylation is required for recruitment of PI3K signaling components. |
| Tissue Specificity: | Highly expressed in spleen, thymus and peripheral blood leukocytes. Highly expressed also in T-cell and monocytic cell lines, expressed at lower level in B-cell lines. Not detected in fibroblast or neuroblastoma cell lines. |
| BioGrid: | 110129. 34 interactions. |
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