Anti-SARS-CoV-2 Spike Protein S1, mAb (Rec, blocking) (Clone: Covi-2) (Azide free)
Figure 1: Binding of human ACE2 to the Spike protein of SARS-CoV-2 is inhibited by the antibody SARS-CoV-2 Spike Protein S1, mAb (rec.) (blocking) (Clone: Covi-2) (Azide free) .
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| Amount : | 100 µg |
| Isotype : | Human IgG1 |
| Purification : | ≥98% (SDS-PAGE) |
| Content : | 1mg/ml. Liquid. In PBS. |
| Storage condition : | Short Term Storage +4°C. Long Term Storage -20°C. Avoid freeze/thaw cycles. Stable for at least 1 year after receipt when stored at -20°C. |
| Uniprot ID : | P0DTC2 |
| Alternative Name : | 2019-nCoV Spike Protein S1 |
| Immunogen Information : | Recombinant SARS-CoV-2 Spike Protein S1 receptor binding domain. |
Coronaviruses (CoVs) are enveloped non-segmented positive-sense single-stranded RNA viruses and can infect respiratory, gastrointestinal, hepatic and central nervous system of human and many other wild animals. Recently, a new severe acute respiratory syndrome β-coronavirus called SARS-CoV-2 (or 2019-nCoV) has emerged, which causes an epidemic of acute respiratory syndrome (called coronavirus human disease 2019 or COVID-19).
SARS-CoV-2 shares 79.5% sequence identity with SARS-CoV and is 96.2% identical at the genome level to the bat coronavirus BatCoV RaTG133, suggesting it had originated in bats. SARS-CoV-2 contains 4 structural proteins, including Envelope (E), Membrane (M), Nucleocapsid (N) and Spike (S), which is a transmembrane protein, composed of two subunits S1 and S2. The S1 subunit contains a receptor binding domain (RBD), which binds to the cell surface receptor Angiotensin-Converting Enzyme 2 (ACE2) present at the surface of epithelial cells, causing mainly infection of human respiratory cells.
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Recognizes and binds to recombinant SARS-CoV-2 Spike Protein S1. It blocks the interaction of SARS-CoV-2 Spike Protein S1 (RBD) to human ACE2. |
For Research Use Only. Not for use in diagnostic/therapeutics procedures.
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