Anti-Rotavirus (Clone: RV6-26)
Roll over image to zoom in
Shipping Info:
For estimated delivery dates, please contact us at [email protected]
| Amount : | 100 µg |
| Isotype : | Human IgG |
| Purification : | ≥95% monomer by analytical SEC |
| Content : | ≥ 5.0 mg/ml Formulation : This recombinant monoclonal antibody is aseptically packaged and formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.2 - 7.4 with no carrier protein, potassium, calcium or preservatives added. |
| Storage condition : | Functional grade preclinical antibodies may be stored sterile as received at 2-8°C for up to one year. For longer term storage, aseptically aliquot in working volumes without diluting and store at ≥ -70°C. Avoid Repeated Freeze Thaw Cycles. |
| Immunogen Information : | Human Mab RV6-26 was sequenced from RV-specific B cells isolated from the blood of healthy adult donors or RV-infected infants or adults |
Reactivity Species : Rotavirus-Virus
Expression Host : HEK-293
Endotoxin Level : ≤ 1.0 EU/mg as determined by the LAL method.
Specificity : RV6-26 activity is directed against a quaternary epitope on VP6. This human monoclonal antibody RV6-26 binds at the viral RNA release pore in the DLP and is able to neutralize RV by inhibiting transcription. Structural data suggest steric hindrance inhibits the transcriptional pore.
Background : Rotaviruses (RV) are double-stranded, non-enveloped, icosahedral RNA viruses in the Reoviridae family that cause severe dehydrating diarrhea in infants and children. RV particles are composed of concentric viral protein (VP) layers. The triple-layered particle has an inner capsid layer (VP2), an intermediate capsid layer (VP6), and an outer capsid layer (VP7, VP4). The transcriptionally active double-layered particle (DLP) consists of VP2 and VP6. VP6 is the most antigenic RV protein in humans. The antibody VH1–46 gene segment is the site of primary interaction with VP65.
|
There are currently no product reviews
|
.png "ACE2/HEK293 Stable Cell Line")
