PE Conjugated Anti-R-Ras2 / TC21 Monoclonal Antibody (Clone:EM-50)
Figure 1: Intracellular staining of R-Ras2/TC21 in HEK-293 R-Ras2 transfectants using monoclonal antibody EM-50, PE.
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| Amount : | 0.1 mg |
| Isotype : | Mouse IgG1 |
| Storage condition : | Store in the dark at 2-8°C. Do not freeze. Avoid prolonged exposure to light. |
R-Ras2 / TC21 is the only member of R-Ras family of small GTPases that shows transforming activities similar to H-Ras, N-Ras, and K-Ras, and it is also structurally similar to them. R-Ras2 seems to play an important role in activating signal transduction pathways that control cell proliferation. Its mutations are associated with the growth of certain tumors, but also overexpression of the wild type form of R-Ras2 has been frequently detected in various carcinomas. Pseudogenes of R-Ras2 gene are found on chromosomes 1 and 2. Alternate splicing results in multiple transcript variants.
| Subcellular location: | Cell membrane |
| Post transnational modification: | May be post-translationally modified by both palmitoylation and polyisoprenylation. |
| Tissue Specificity: | Ubiquitously present in all tissues examined, with the highest levels in heart, placenta, and skeletal muscle. Moderate levels in lung and liver; low levels in brain, kidney, and pancreas. |
| BioGrid: | 116480. 40 interactions. |
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