Anti-PD-1 Monoclonal Antibody (Clone:IHC001)

Product code: 44-1067

Clone name : IHC001
Clonality : Monoclonal
Application : IHC
Reactivity : Human

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Available Pack Size(s)

  •   0.1 ml

  •  0.5 ml

  • $354.00 

  • $485.00 

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Format : Purified
Amount : 0.5 ml
Isotype : Mouse IgG2b
Purification : Protein A/G Chromatography
Content : Tris Buffer, pH 7.3 - 7.7, with 1% BSA and <0.1% Sodium Azide
Storage condition : Store at 2°C - 8°C. Do not freeze.
Gene : PDCD1
Gene ID : 5133
Uniprot ID : Q15116
Alternative Name : PDCD1, PD1
Immunogen Information : Recombinant human His-PD1

Programmed Death 1 (PD-1) is a member of the CD28/CTLA-4 family of T-cell regulators, expressed as a co-receptor on the surface of activated T-cells, B-cells, and macrophages. New studies have suggested that the PD-1/PD-L1 signaling pathway may be linked to anti-tumor immunity, as PD-L1 has been shown to induce apoptosis of activated T cells or inhibit activity of cytotoxic T cells. In comparison to CD10 and Bcl-6, PD-1 is expressed by fewer B cells and has therefore been considered a more specific marker for angioimmunoblastic T-cell lymphoma. Therapies targeted toward the PD-1 receptor have shown remarkable clinical responses in patients with various types of cancer, including non–small-cell lung cancer, melanoma, and renal-cell cancer.

Recommended dilutions: Immunohistochemical analysis: 1:100 - 1:200. However, this need to be optimized based on the research applications.

For Research Use Only. Not for use in diagnostic/therapeutics procedures.

Subcellular location: Membrane
BioGrid: 111160. 61 interactions.
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