PE Conjugated, Anti-PCNA Monoclonal Antibody (Clone:PC10)
Figure 1: Intracellular staining of PCNA in K562 cells with anti-PCNA (PC10) PE.
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| Amount : | 100 tests |
| Isotype : | Mouse IgG2a |
| Storage condition : | Store in the dark at 2-8°C. Do not freeze. Avoid prolonged exposure to light. |
PCNA (proliferating cell nuclear antigen), which is the DNA polymerase delta auxiliary protein acting in homotrimeric form to increase the processivity of leading strand synthesis during DNA replication. PCNA is expressed in the nucleus of all proliferating cells. In response to DNA damage, it is ubiquitinated and is involved in the RAD6-dependent DNA repair pathway. PCNA is a useful marker of DNA synthesis, as its form not involved in DNA synthesis degradates in histological preparations in the presence of organic solvents.
| Subcellular location: | Nucleus |
| Post transnational modification: | Methylated on glutamate residues by ARMT1/C6orf211. |
| BioGrid: | 111142. 314 interactions. |
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