Anti-PAPP-A / Pappalysin-1 (Marker of Atherosclerosis and Aneuploid Fetus) Monoclonal Antibody(Clone: PAPPA/2716)
Fig. 1: Formalin-fixed, paraffin-embedded human Placenta stained with PAPP-A Mouse Monoclonal Antibody (PAPPA/2716).
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| Amount : | 100 µg |
| Isotype : | Mouse IgG2b, kappa |
| Content : | 200 µg/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml. |
| Storage condition : | Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. |
| Gene : | PAPPA |
| Gene ID : | 5069 |
| Uniprot ID : | Q13219 |
| Alternative Name : | ASBABP2; Aspecific BCL2 ARE binding protein 2; Differentially placenta 1 expressed protein; DIPLA1; IGF-dependent; IGFBP4ase; Insulin-like growth factor-dependent IGF-binding protein 4 protease (IGFBP-4 protease); PAPA; PAPP A; PAPPA1; Pappalysin-1; Pregnancy Associated Plasma Protein A (PAPP-A) |
| Immunogen Information : | Recombinant fragment (within aa 351-523) of human PAPP-A protein (exact sequence is proprietary) |
Pregnancy Associated Plasma Protein (PAPP-A) is found in maternal blood that increases as pregnancy progresses, althoµgh it is not specific to pregnancy. It is principally expressed in the syncytiotrophoblast of the placenta, which forms the main source of circulating maternal PAPP-A. It cleaves insulin-like growth factor binding proteins (IGFBPs), IGFBP-4 and IGFBP-5. IGFBP-4 cleavage is enhanced significantly in the presence of bound IGF, whereas IGFBP-5 cleavage is inhibited slightly by IGF presence. It is thoµght to be involved in local proliferative processes such as wound healing and bone remodeling. Low plasma level of this protein has been sµggested as a biochemical marker for pregnancies with aneuploid fetuses. PAPPA has also been sµggested as a potential biomarker of acute myocardial infarction and Coronary Artery Disease (CAD).
Immunohistochemistry (Formalin-fixed) (1-2ug/ml for 30 minutes at RT)(Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes);
For Research Use Only. Not for use in diagnostic/therapeutics procedures.
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