Anti-PAG / Cbp Monoclonal Antibody (Clone:PAG-C1)
Figure 1: Immunoprecipitation of human PAG/Cbp from the lysate of RAJI human Burkitt lymphoma cell line.Western blot was immunostained with anti-human PAG (MEM-255; ). Note: PAG/Cbp is a 46 kDa adaptor protein, which however migrates on SDS PAGE gels anomalously as an 80 kDa molecule. Lane 2: immunoprecipitation with anti-PAG (PAG-C1). Lane 3: immunoprecipitation with anti-PAG (polyclonal antibody)
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Format : | Purified |
Amount : | 0.1 mg |
Isotype : | Mouse IgG2b |
Purification : | Purified by protein-A affinity chromatography |
Storage condition : | Store at 2-8°C. Do not freeze. |
Immunoprecipitation Positive control: RAJI human Burkitt lymphoma cell line
For Research Use Only. Not for use in diagnostic/therapeutics procedures.
Subcellular location: | Cell membrane |
Post transnational modification: | Phosphorylated by FYN on Tyr-317 in resting T-cells; which promotes interaction with CSK. Dephosphorylated by PTPRC/CD45 upon TCR activation; which leads to CSK dissociation. May also be dephosphorylated by PTPN11. Hyperphosphorylated in mast cells upon FCER1 activation. Phosphorylated by LYN. |
Tissue Specificity: | Ubiquitously expressed. Present in germinal center B-cells, plasma cells, T-cells, monocytes and platelets (at protein level). |
BioGrid: | 120931. 42 interactions. |
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