Anti-P53 VHH antibody

Alpaca derived anti-p53 VHH single domain antibody (molecular weight: 14.6 kDa) with a 6*His tag at its C-terminal, expressed in E. coli under conditions free from animal derived components.

 This gene encodes tumor protein p53, which responds to diverse cellular stresses to regulate target genes that induce cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. p53 protein is expressed at low level in normal cells and at a high level in a variety of transformed cell lines, where it's believed to contribute to transformation and malignancy. p53 is a DNA-binding protein containing transcription activation, DNA-binding, and oligomerization domains. It is postulated to bind to a p53-binding site and activate expression of downstream genes that inhibit growth and/or invasion, and thus function as a tumor suppressor. Mutants of p53 that frequently occur in a number of different human cancers fail to bind the consensus DNA binding site, and hence cause the loss of tumor suppressor activity. Alterations of this gene occur not only as somatic mutations in human malignancies, but also as germline mutations in some cancer-prone families with Li-Fraumeni syndrome. Multiple p53 variants due to alternative promoters and multiple alternative splicing have been found. These variants encode distinct isoforms, which can regulate p53 transcriptional activity.

Specificity: p53, Tp53, p53 tumor suppressor

This is a product from Jotbody, Hong Kong. This antibody is made available worldwide by ABEOMICS Inc.

Positive controls: Positive ELISA detected in: p53
Recommended dilutions :ELISA 1:1000-1:10000

For Research Use Only. Not for use in diagnostic/therapeutics procedures.