Anti-p21Waf1 Monoclonal Antibody (Clone:WA-1)(Discontinued)

Product code: 30-1216

Clone name : WA-1
Clonality : Monoclonal
Application : WB
Reactivity : Human

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Format : Purified
Amount : 0.1 mg
Isotype : Mouse IgG1
Purification : Purified by protein-A affinity chromatography
Storage condition : Store at 2-8°C. Do not freeze.
Gene : CDKN1A
Gene ID : 1026
Uniprot ID : P38936
Alternative Name : CDKN1A, CAP20, CDKN1, CIP1, MDA6, PIC1, SDI1, WAF1
Immunogen Information : Human p21 protein

The tumour suppressor p21Waf1 (Wild-type p53-Activated Fragment 1; also known as Cip1, Cdk interacting protein, or SDI 1) is a cyclin-dependent kinase (Cdk) inhibitor, which is expressed by involvement of p53, Egr-1, AP2, STATs or other transcription factors upon various stimuli resulting in cell cycle arrest. Through its N-terminal domain p21Waf1 inhibits Cdk activity, whereas through the C-terminal domain it inhibits the activity of PCNA (proliferating cell nuclear antigen) to activate DNA replication. Cytosolic location of p21 counteracts its inhibitory activities.

Immunofluoroscence Immunohistochemistry Positive tissue: colon carcinoma

For Research Use Only. Not for use in diagnostic/therapeutics procedures.

Subcellular location: Cytoplasm, Nucleus
Post transnational modification: Acetylation leads to protein stability. Acetylated in vitro on Lys-141, Lys-154, Lys-161 and Lys-163. Deacetylation by HDAC1 is prevented by competitive binding of C10orf90/FATS to HDAC1 (By similarity).
Tissue Specificity: Expressed in all adult tissues, with 5-fold lower levels observed in the brain.
BioGrid: 107460. 284 interactions.
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