Anti-Notch 1 Monoclonal Antibody (Clone:mN1A)

Product code: 30-1459

Clone name : mN1A
Clonality : Monoclonal
Application : FACS
Reactivity : Human

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0.1 mg
$389.00 

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Format : Purified
Amount : 0.1 mg
Isotype : Mouse IgG1
Purification : Purified by protein-A affinity chromatography
Storage condition : Store at 2-8°C. Do not freeze.
Gene : Notch1
Gene ID : 18128
Uniprot ID : Q01705
Alternative Name : NOTCH1, TAN1, Motch A, mT14, p300
Immunogen Information : GST fusion protein containing cdc10-NCR region of mouse Notch1

Notch 1 is a 270-300 kDa transmembrane heterodimeric protein with multiple extracellular growth factor-like repeats, and with an intracellular domain consisting of multiple different domain types. It serves as a receptor for membrane ligands, such as Delta 1, Jagged1 (CD339), and Jagged2, and regulates cell fate decisions. Upon ligand binding the transmembrane form of Notch 1 is repeatedly cleaved to provide approximately 120 kDa Notch intracellular fragment (NICD), which translocates to the nucleus and acts as a part of transcriptional complexes that alter differentiation, proliferation, and apoptosis. The highest level of Notch 1 expression is in brain, lung and thymus.

Subcellular location: Nucleus
Post transnational modification: Hydroxylated at Asn-1955 by HIF1AN. Hydroxylated at Asn-2022 by HIF1AN (By similarity). Hydroxylation reduces affinity for HI1AN and may thus indirectly modulate negative regulation of NICD (By similarity).
Tissue Specificity: In fetal tissues most abundant in spleen, brain stem and lung. Also present in most adult tissues where it is found mainly in lymphoid tissues.
BioGrid: 110913. 223 interactions.
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