PE Conjugated Anti-NG2 / Chondroitin sulfate proteoglycan 4 Monoclonal Antibody (Clone:7.1)
Figure 1: Surface staining of SK-MEL-30 cells with anti-NG2 (7.1) PE (red; blank orange); and SP2 cells (negative, blue; blank green).
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| Amount : | 100 tests |
| Isotype : | Mouse IgG1 |
| Storage condition : | Store in the dark at 2-8°C. Do not freeze. Avoid prolonged exposure to light. |
NG2 / Chondroitin sulfate proteoglycan 4 is expressed on glial cell populations, but not on normal hepatopoietic cells. It is an integral membrane chondroitin sulfate proteoglycan expressed by human malignant melanoma cells, where it plays role in stabilizing cell-substratum interactions during early events of melanoma cell spreading on endothelial basement membranes, and supports signaling pathways important for tumor invasion and growth. NG2 also serves as an AML blast tumor marker associated with poor prognosis.
| Subcellular location: | Cell membrane, Apical cell membrane, Cell projection, Cell surface |
| Post transnational modification: | Phosphorylation by PRKCA regulates its subcellular location and function in cell motility. |
| Tissue Specificity: | Detected only in malignant melanoma cells. |
| BioGrid: | 107846. 13 interactions. |
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