Anti-NG2 / Chondroitin sulfate proteoglycan 4 Monoclonal Antibody (Clone:7.1)
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| Format : | Purified |
| Amount : | 0.1 mg |
| Isotype : | Mouse IgG1 |
| Purification : | Purified by protein-A affinity chromatography |
| Storage condition : | Store at 2-8°C. Do not freeze. |
NG2 / Chondroitin sulfate proteoglycan 4 is expressed on glial cell populations, but not on normal hepatopoietic cells. It is an integral membrane chondroitin sulfate proteoglycan expressed by human malignant melanoma cells, where it plays role in stabilizing cell-substratum interactions during early events of melanoma cell spreading on endothelial basement membranes, and supports signaling pathways important for tumor invasion and growth. NG2 also serves as an AML blast tumor marker associated with poor prognosis.
| Subcellular location: | Cell membrane, Apical cell membrane, Cell projection, Cell surface |
| Post transnational modification: | Phosphorylation by PRKCA regulates its subcellular location and function in cell motility. |
| Tissue Specificity: | Detected only in malignant melanoma cells. |
| BioGrid: | 107846. 13 interactions. |
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