Anti-Ms CD18 Purified Low Endotoxin

Product code: 30-2821

Clone name : M18/2
Clonality : Monoclonal
Application : FACS, IP, WB, IHC, IHC-Fr, FUNC
Reactivity : Mouse
Conjugate : Purified Low Endotoxin

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0.1 mg
$380.00 

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Amount : 0.1 mg
Purification : Purified by protein-G affinity chromatography.
Content : Concentration: 1 mg/ml
Storage Buffer: Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
Storage condition : Store at 2-8°C. Do not freeze.
Gene : Itgb2
Gene ID : 16414
Uniprot ID : P11835
Alternative Name : integrin subunit beta 2 Integrin beta2, Complement receptor C3 subunit beta, ITGB2
Immunogen Information : Murine cytotoxic T cell glycoproteins
CD18, integrin beta2 subunit, forms heterodimers with four types of CD11 molecule to constitute leukocyte (beta2) integrins: alphaLbeta2 (CD11a/CD18, LFA-1), alphaMbeta2 (CD11b/CD18, Mac-1, CR3), alphaXbeta2 (CD11c/CD18) and alphaDbeta2 (CD11d/CD18). In most cases, the response mediated by the integrin is a composite of the functions of its individual subunits. These integrins are essential for proper leukocyte migration, mediating intercellular contacts. Absence of CD18 leads to leukocyte adhesion deficiency-1; severe reduction of CD18 expression leads to the development of a psoriasiform skin disease. CD18 is also a target of Mannheimia (Pasteurella) haemolytica leukotoxin and is sufficient to mediate leukotoxin-mediated cytolysis.
Specificity :The rat monoclonal antibody M18/2 recognizes an extracellular epitope of CD18 antigen (integrin beta2 subunit; beta2 integrin), a 95 kDa type I transmembrane protein expressed on all leukocytes.

Functional application: Blocking or stimulation.
Flow cytometry: Recommended dilution: 1 µg/ml.

For Research Use Only. Not for use in diagnostic/therapeutics procedures.

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