Anti-Ms CD11b FITC

Product code: 30-2830

Clone name : M1/70
Clonality : Monoclonal
Application : FACS
Reactivity : Mouse, Rabbit, Human, Non-human primates
Conjugate : FITC

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0.1 mg
$372.00 

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Amount : 0.1 mg
Purification : Purified antibody is conjugated with fluorescein isothiocyanate (FITC) under optimum conditions and unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography.
Content : Concentration: 0.5 mg/ml
Storage Buffer: Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
Storage condition : Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.
Gene : Itgam
Gene ID : 16409
Uniprot ID : G5E8F1
Alternative Name : integrin subunit alpha M Mac-1, Integrin alpha M, ITGAM, CR3A, MO1A, MAC1A
Immunogen Information : B10 mouse spleen cells enriched for T cells
CD11b (integrin alphaM subunit) is a 165-170 kDa type I transmembrane glycoprotein that non-covalently associates with integrin beta2 subunit (CD18); expression of the CD11b chain on the cell surface requires the presence of the CD18 antigen. CD11b/CD18 integrin (Mac-1, CR3) is highly expressed on NK cells, neutrophils, monocytes and less on macrophages. CD11b/CD18 integrin is implicated in various adhesive interactions of monocytes, macrophages and granulocytes, facilitating their diapedesis, as well as it mediates the uptake of complement coated particles, serving as a receptor for the iC3b fragment of the third complement component.
Specificity :The rat monoclonal antibody M1/70 detects an extracellular epitope of CD11b (integrin alphaM subunit), a type I transmembrane protein mainly expressed on monocytes/macrophages, granulocytes and NK-cells, which associates with CD18 to form Mac-1 integrin that plays important role in cell-cell interactions.

Flow cytometry: Recommended dilution: 1-3 µg/ml.

For Research Use Only. Not for use in diagnostic/therapeutics procedures.

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