Anti-MRCK alpha Polyclonal Antibody(Discontinued)
Figure 1: Colocalization between endogenous MRCK (red) and transferrin-Dyomics 547 (green) after 10 min. incubation of the cells (HeLa) with transferrin-Dyomics 547. Immunostaining with polyclonal anti-MRCK alpha.
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| Format : | Purified |
| Amount : | 0.1 mg |
| Isotype : | Rabbit IgG |
| Purification : | Purified from rabbit serum by affinity chromatography |
| Storage condition : | Store at 2-8°C. Do not freeze. |
MRCK alpha (myotonic dystrophy kinase-related Cdc42-binding kinase alpha) is a member of the dystrophia myotonica protein kinase (DMPK) family that functions downstream of Cdc42 in actin cytoskeletal reorganization. It is a serine/threonine kinase with multiple functional domains, including phorbol ester-responsive C1 domain. Three independent coiled-coil domains and the N-terminal region preceding the kinase domain are responsible for intermolecular interactions leading to MRCK alpha multimerization. The transautophosphorylation process is critical for regulation of MRCK alpha catalytic activities. Binding of phorbol esters to MRCK releases its autoinhibition, allowing N-terminal dimerization and subsequent kinase activation.
| Subcellular location: | Cytoplasm, Cell projection |
| Tissue Specificity: | Abundant in the heart, brain, skeletal muscle, kidney, and pancreas, with little or no expression in the lung and liver. |
| BioGrid: | 114051. 32 interactions. |
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