Azide free Anti-MHC Class II Monoclonal Antibody (Clone:M5/114)

Product code: 30-1031

Clone name : M5/114
Clonality : Monoclonal
Application : FACS
Reactivity : Mouse

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0.1 mg
$380.00 

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Amount : 0.1 mg
Isotype : Rat IgG2b
Purification : Purified by protein-G affinity chromatography
Storage condition : Store at 2-8°C. Do not freeze.
Gene : Ciita
Gene ID : 12265
Uniprot ID : P79621
Alternative Name : Ciita, C2ta, Mhc2ta
Immunogen Information : Activated C57BL/6 mouse spleen cells

MHC (major histocompatibility complex) class II molecules are transmembrane glycoproteins expressed on the surface of professional antigen-presenting cells, such as macrophages, dendritic cells and B cells. Before their exposition on the cell surface, the MHC class II molecules react with endocytosed exogenous antigens, which are then presented to the T cells. The antigen-binding grove between MHC class II alpha and beta chain is open at both ends and is 15-24 amino acid residues long.

Flow Cytometry Recommended dilution: 2 µg/ml
Immunoprecipitation Western Blotting Immunohistochemistry Immunohistochemistry (frozen sections) Functional Application Blocking of T cell proliferative responses

For Research Use Only. Not for use in diagnostic/therapeutics procedures.

Subcellular location: Nucleus, Nucleus
Post transnational modification: Autophosphorylated, affecting interaction with TAF7.
Tissue Specificity: Isoform 1 is expressed at very high levels in dendritic cells, at very low levels in spleen and thymus and is not detected in other tissues. Isoform 2 is detected at high levels in spleen and tonsil as well as in a number of B-lymphocyte cell lines, and at very low levels in dendritic cells.
BioGrid: 198417. 9 interactions.
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