FITC Conjugated Anti-MHC Class II Monoclonal Antibody (Clone:M5/114)
Figure 1: Flow cytometry analysis (surface staining) of MHCII on murine splenocytes with anti-MHCII (M5/114) FITC.
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| Amount : | 0.1 mg |
| Isotype : | Rat IgG2b |
| Storage condition : | Store in the dark at 2-8°C. Do not freeze. Avoid prolonged exposure to light. |
MHC (major histocompatibility complex) class II molecules are transmembrane glycoproteins expressed on the surface of professional antigen-presenting cells, such as macrophages, dendritic cells and B cells. Before their exposition on the cell surface, the MHC class II molecules react with endocytosed exogenous antigens, which are then presented to the T cells. The antigen-binding grove between MHC class II alpha and beta chain is open at both ends and is 15-24 amino acid residues long.
| Subcellular location: | Nucleus, Nucleus |
| Post transnational modification: | Autophosphorylated, affecting interaction with TAF7. |
| Tissue Specificity: | Isoform 1 is expressed at very high levels in dendritic cells, at very low levels in spleen and thymus and is not detected in other tissues. Isoform 2 is detected at high levels in spleen and tonsil as well as in a number of B-lymphocyte cell lines, and at very low levels in dendritic cells. |
| BioGrid: | 198417. 9 interactions. |
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