Anti-MDM2 Monoclonal Antibody(Clone: MDM2/2414)

Name: Anti-MDM2 Monoclonal Antibody(Clone: MDM2/2414)
Brand: Abeomics
SKU: 36-2761
Price: 520.0000 USD
Availability: InStock
Rating: 4.7 (10 reviews)

Fig. 1: Formalin-fixed, paraffin-embedded human Pancreas stained with MDM2 Mouse Monoclonal Antibody (MDM2/2414).

Anti-MDM2 Monoclonal Antibody(Clone: MDM2/2414)

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Fig. 1: Formalin-fixed, paraffin-embedded human Pancreas stained with MDM2 Mouse Monoclonal Antibody (MDM2/2414).

Fig. 2: SDS-PAGE Analysis Purified MDM2 Mouse Monoclonal Antibody (MDM2/2414). Confirmation of Integrity and Purity of Antibody.

Fig. 3: Analysis of Protein Array containing more than 19,000 full-length human proteins using MDM2 Mouse Monoclonal Antibody (MDM2/2414). Z- and S- Score: The Z-score represents the strength of a signal that a monoclonal antibody (Monoclonal Antibody) (in combination with a fluorescently-tagged anti-IgG secondary antibody) produces when binding to a particular protein on the HuProtTM array. Z-scores are described in units of standard deviations (SD's) above the mean value of all signals generated on that array. If targets on HuProtTM are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD's) between the Z-score. S-score therefore represents the relative target specificity of a Monoclonal Antibody to its intended target. A Monoclonal Antibody is considered to specific to its intended target, if the Monoclonal Antibody has an S-score of at least 2.5. For example, if a Monoclonal Antibody binds to protein X with a Z-score of 43 and to protein Y with a Z-score of 14, then the S-score for the binding of that Monoclonal Antibody to protein X is equal to 29.

Product code: 36-2761

Clone name :	MDM2/2414
Clonality :	Monoclonal
Application :	IHC
Reactivity :	Human

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Shipping Info:

For estimated delivery dates, please contact us at [email protected]

Download TDS MSDS

Amount :	100 µg
Isotype :	Mouse IgG1, kappa
Content :	200 µg/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Storage condition :	Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous.


Gene :	MDM2
Gene ID :	4193
Uniprot ID :	Q00987
Alternative Name :	ACTFS; Double minute 2 protein; E3 ubiquitin-protein ligase; Hdm2; HDMX; MDM2; MDM2 oncogene E3 ubiquitin protein ligase; MDM2BP; Mouse Double Minute 2; MTBP; Murine Double Minute Chromosome 2; p53 Binding Protein Mdm2; p53-binding protein Mdm2
Immunogen Information :	Recombinant human MDM2 protein fragment (around aa 126-254) (exact sequence is proprietary)

MDM2 is a nuclear phosphoprotein that binds and inhibits transactivation by tumor protein p53. It can promote tumor formation by targeting tumor suppressor proteins, such as p53, for proteasomal degradation. Overexpression of MDM2 can result in excessive inactivation of tumor protein p53, diminishing its tumor suppressor function. This protein also affects the cell cycle, apoptosis, and tumorigenesis throÂµgh interactions with other proteins, including retinoblastoma 1 and ribosomal protein L5. Overexpression of MDM2 protein is detected in a variety of cancers.

Immunohistochemistry (Formalin-fixed) (1-2ug/ml for 30 minutes at RT),(Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95 °C followed by cooling at RT for 20 minutes),

For Research Use Only. Not for use in diagnostic/therapeutics procedures.

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