Anti-MCAM (Melanoma Cell Adhesion Molecule) / MUC18 / CD146 Monoclonal Antibody(Clone: MCAM/3048)

Name: Anti-MCAM (Melanoma Cell Adhesion Molecule) / MUC18 / CD146 Monoclonal Antibody(Clone: MCAM/3048)
Brand: Abeomics
SKU: 36-2745
Price: 520.0000 USD
Availability: InStock
Rating: 4.6 (10 reviews)

Fig. 1: Formalin-fixed, paraffin-embedded human Melanoma stained with MCAM Mouse Monoclonal Antibody (MCAM/3048).

Anti-MCAM (Melanoma Cell Adhesion Molecule) / MUC18 / CD146 Monoclonal Antibody(Clone: MCAM/3048)

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Fig. 1: Formalin-fixed, paraffin-embedded human Melanoma stained with MCAM Mouse Monoclonal Antibody (MCAM/3048).

Fig. 2: Formalin-fixed, paraffin-embedded human Melanoma stained with MCAM Mouse Monoclonal Antibody (MCAM/3048).

Fig. 3: Analysis of Protein Array containing more than 19,000 full-length human proteins using MCAM Mouse Monoclonal Antibody (MCAM/3048). Z- and S- Score: The Z-score represents the strength of a signal that a monoclonal antibody (Monoclonal Antibody) (in combination with a fluorescently-tagged anti-IgG secondary antibody) produces when binding to a particular protein on the HuProtTM array. Z-scores are described in units of standard deviations (SD’s) above the mean value of all signals generated on that array. If targets on HuProtTM are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD’s) between the Z-score. S-score therefore represents the relative target specificity of a Monoclonal Antibody to its intended target. A Monoclonal Antibody is considered to specific to its intended target, if the Monoclonal Antibody has an S-score of at least 2.5. For example, if a Monoclonal Antibody binds to protein X with a Z-score of 43 and to protein Y with a Z-score of 14, then the S-score for the binding of that Monoclonal Antibody to protein X is equal to 29.

Product code: 36-2745

Clone name :	MCAM/3048
Clonality :	Monoclonal
Application :	IHC
Reactivity :	Human

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Shipping Info:

For estimated delivery dates, please contact us at [email protected]

Download TDS MSDS

Amount :	100 µg
Isotype :	Mouse IgG2b, kappa
Content :	200 µg/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Storage condition :	Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous.


Gene :	MCAM
Gene ID :	4162
Uniprot ID :	P43121
Alternative Name :	Cell Surface Glycoprotein MUC18, Cell Surface Glycoprotein P1H12, Gicerin, Melanoma Adhesion Molecule (MCAM), Melanoma Associated Glycoprotein MUC18, Melanoma Cell Adhesion Molecule, Melanoma-associated Antigen A32, Mel-CAM, S-endo 1 Endothelial-associated Antigen, Sendo1
Immunogen Information :	Recombinant human MCAM protein fragment (around aa226-374) (exact sequence is proprietary)

The human Mel-CAM gene maps to chromosome 11q23 and encodes a trans-membrane glycoprotein, also designated MCAM, MUC 18 or CD146, that belongs to the immunoglobulin superfamily and functions as a Ca2+-independent cell adhesion molecule. Mel-CAM expression is restricted to advanced primary and metastatic melanomas and to cell lines of the neuroectodermal lineage, but not normal melanocytes. Mel-CAM is found on 80% of advanced primary human melanomas and correlates well with development of metastatic disease.

Immunohistochemistry (Formalin-fixed) (1-2ug/ml for 30 minutes at RT),(Staining of formalin-fixed tissues requires heating tissue sections in 1mM EDTA, pH 8.0, for 45 min at 95°C followed by cooling at RT for 20 minutes),

For Research Use Only. Not for use in diagnostic/therapeutics procedures.

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