Anti-MART-1 / Melan-A / MLANA (Melanoma Marker) Recombinant Mouse Monoclonal Antibody (Clone:rMLANA/1905)
Figure 1: SDS-PAGE Analysis of Purifed MART-1 Mouse Recombiannt Monoclonal Antibody (rMLANA/1905).
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| Format : | Purified |
| Amount : | 100 µg |
| Purification : | Protein A/G |
| Content : | 200µg/ml of recombinant MAb purified by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml. |
| Storage condition : | Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. |
This antibody recognizes a protein doublet of 20-22kDa, identified as MART-1 (Melanoma Antigen Recognized by T cells 1) or Melan-A. MART-1 is a newly identified melanocyte differentiation antigen recognized by autologous cytotoxic T lymphocytes. Seven other melanoma associated antigens recognized by autologous cytotoxic T cells include MAGE-1, MAGE-3, tyrosinase, gp100, gp75, BAGE-1, and GAGE-1. Subcellular fractionation shows that MART-1 is present in melanosomes and endoplasmic reticulum. This MAb labels melanomas and other tumors showing melanocytic differentiation. It is also a useful positive-marker for angiomyolipomas. It does not stain tumor cells of epithelial, lymphoid, glial, or mesenchymal origin.
| Subcellular location: | Endoplasmic reticulum membrane, Golgi apparatus, Golgi apparatus, Melanosome |
| Post transnational modification: | Acylated. |
| Tissue Specificity: | Expression is restricted to melanoma and melanocyte cell lines and retina. |
| BioGrid: | 108604. 2 interactions. |
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