Anti-Lymphocyte Specific Protein 1 (LSP1) / pp52 Monoclonal Antibody(Clone: LSP1/3025)

Name: Anti-Lymphocyte Specific Protein 1 (LSP1) / pp52 Monoclonal Antibody(Clone: LSP1/3025)
Brand: Abeomics
SKU: 36-2709
Price: 520.0000 USD
Availability: InStock
Rating: 4 (10 reviews)

Fig. 1: Formalin-fixed, paraffin-embedded human Lymph Node stained with Monospecific Mouse Monoclonal Antibody to LSP1 (LSP1/3025).

Anti-Lymphocyte Specific Protein 1 (LSP1) / pp52 Monoclonal Antibody(Clone: LSP1/3025)

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Fig. 1: Formalin-fixed, paraffin-embedded human Lymph Node stained with Monospecific Mouse Monoclonal Antibody to LSP1 (LSP1/3025).

Fig. 2: Formalin-fixed, paraffin-embedded human Lymphoma stained with Monospecific Mouse Monoclonal Antibody to LSP1 (LSP1/3025).

Fig. 3: SDS-PAGE Analysis Purified Monospecific Mouse Monoclonal Antibody to LSP1 (LSP1/3025). Confirmation of Purity and Integrity of Antibody.

Fig. 4: Analysis of Protein Array containing more than 19,000 full-length human proteins using LSP1 Mouse Monoclonal Antibody (LSP1/3025). Z- and S- Score: The Z-score represents the strength of a signal that a monoclonal antibody (MAb) (in combination with a fluorescently-tagged anti-IgG secondary antibody) produces when binding to a particular protein on the HuProtTM array. Z-scores are described in units of standard deviations (SD's) above the mean value of all signals generated on that array. If targets on HuProtTM are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD's) between the Z-score. S-score therefore represents the relative target specificity of a MAb to its intended target. A MAb is considered to specific to its intended target, if the MAb has an S-score of at least 2.5. For example, if a MAb binds to protein X with a Z-score of 43 and to protein Y with a Z-score of 14, then the S-score for the binding of that MAb to protein X is equal to 29.

Product code: 36-2709

Clone name :	LSP1/3025
Clonality :	Monoclonal
Application :	IHC
Reactivity :	Human

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Shipping Info:

For estimated delivery dates, please contact us at [email protected]

Download TDS MSDS

Amount :	100 µg
Isotype :	Mouse IgG1, kappa
Content :	200 µg/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Storage condition :	Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous.


Gene :	LSP1
Gene ID :	4046
Uniprot ID :	P33241
Alternative Name :	WP34, pp52, lymphocyte specific protein 1, leukocyte specific protein 1
Immunogen Information :	Recombinant fragment of human LSP1 protein (around aa174-278) (exact sequence is proprietary)

LSP1 is a hematopoietic-expressed gene that encodes an F-actin-binding, leukocyte-specific (including B and T lymphocytes, granulocytes and macrophages), phosphoprotein. However, mRNA splice variants that do not encode the lympho-specific protein are expressed from this gene in nonlymphoid cell lines as well (myocytes, stromal cells and fibroblasts), sÂµggesting pp52 has a divergent role in signal transduction. The pp52 (LSP1) locus maps to human chromosome 11p15.5, which is implicated in tumor-related chromosomal translocations found in chronic lymphocytic leukemia. The pp52 promoter contains key elements that control transcriptional activity including an initiator specifying the unique 5' terminus of pp52 mRNA, tandem pairs of Ets and SP1 motifs, and a single C/EBP motif. LSP1 binds the cytoskeleton and has been implicated in affecting cytoskeletal remodeling in a variety of leukocyte functions, including cell motility and chemotaxis.

Immunohistochemistry (Formalin-fixed) (1-2ug/ml for 30 minutes at RT)(Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes)

For Research Use Only. Not for use in diagnostic/therapeutics procedures.

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