Anti-LST1 Monoclonal Antibody (Clone:LST1/02)
Figure 1: Western Blotting analysis (non-reducing conditions) of LST1 in whole cell lysate of U937 human Caucasian histiocytic lymphoma cell line. Lane 1: immunostaining with Isotype mouse IgG1 control (PPV-06; ). Lane 2-3: immunostaining with anti-human LST1 (LST1/02), two independent batches.Note: It migrates on SDS PAGE gels as approximately 25-28 kDa molecule.
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| Format : | Purified |
| Amount : | 0.1 mg |
| Isotype : | Mouse IgG1 |
| Purification : | Purified by protein-A affinity chromatography |
| Storage condition : | Store at 2-8°C. Do not freeze. |
LST1 (leukocyte-specific transcript, also known as B144) is expressed in cells of myeloid/erythroid lineage (monocytes, granulocytes, dendritic cells, platelets, erythrocytes). At least 14 alternatively spliced variants (LST1/A - LST1/N) can be detected; some of them (LST1/A, B, C, G, I, K) are transmembrane cell surface-exposed forms, the other are soluble. LST1 induces production of long, thin filopodia in dendritic cells, has an inhibitory effect on lymphocyte proliferation and may have an immunomodulatory role. LST1/A is an 11 kDa transmembrane adaptor present in membrane rafts and forms spontaneously covalent homodimers. Its intracellular domain contains two tyrosine motifs, one of them being an ITIM very similar to such motifs in Siglec.
| Subcellular location: | Membrane, Golgi apparatus membrane, Endomembrane system |
| Tissue Specificity: | Expressed in lung, tonsil, thymus, placenta, kidney, fetal spleen, fetal liver and brain. |
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