Anti-LIME Polyclonal Antibody
Figure 1: Immunohistochemistry staining of human spleen (paraffin sections) with anti-LIME polyclonal antibody.
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| Format : | Purified |
| Amount : | 0.1 mg |
| Isotype : | Rabbit IgG |
| Purification : | Purified from rabbit serum by precipitation methods |
| Storage condition : | Store at 2-8°C. Do not freeze. |
LIME (Lck-interacting molecule) is a 30 kDa double-palmitoylated protein with unusually basic cytoplasmic domain, expressed by T cells. After ligation of CD4 or CD8 T cell coreceptors, LIME is phosphorylated by Src-family kinases and associates with Lck and Fyn kinases and with their negative regulator Csk. Interestingly, Csk-mediated phosphorylation of C-terminal negative-regulatory tyrosine of LIME-associated Lck can result in increase of enzymatic activity compared with the total pool of Lck, thus, LIME serves as a positive regulator of TCR-dependent T cell signaling. However, under some circumstances, LIME may mediate inhibitory signals.
| Subcellular location: | Cell membrane |
| Post transnational modification: | Phosphorylated on tyrosines upon TCR activation and/or CD4 coreceptor stimulation, or upon BCR stimulation; which leads to the recruitment of SH2-containing proteins. |
| Tissue Specificity: | Expressed in peripheral blood lymphocytes, lymphoid tissues, and liver. Present in T-cells and plasma cells, and in various hematopoietic cell lines (at protein level). |
| BioGrid: | 120264. 4 interactions. |
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