Anti-LIME Polyclonal Antibody

Product code: 30-1281

Clonality : Polyclonal
Application : WB, IHC
Reactivity : Human

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0.1 mg
$433.00 

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Format : Purified
Amount : 0.1 mg
Isotype : Rabbit IgG
Purification : Purified from rabbit serum by precipitation methods
Storage condition : Store at 2-8°C. Do not freeze.
Gene : LIME1
Gene ID : 54923
Uniprot ID : Q9H400
Alternative Name : LIME1, LIME, LP8067
Immunogen Information : Bacterially expressed intracellular fragment corresponding to aa 141-295 of human LIME.
LIME (Lck-interacting molecule) is a 30 kDa double-palmitoylated protein with unusually basic cytoplasmic domain, expressed by T cells. After ligation of CD4 or CD8 T cell coreceptors, LIME is phosphorylated by Src-family kinases and associates with Lck and Fyn kinases and with their negative regulator Csk. Interestingly, Csk-mediated phosphorylation of C-terminal negative-regulatory tyrosine of LIME-associated Lck can result in increase of enzymatic activity compared with the total pool of Lck, thus, LIME serves as a positive regulator of TCR-dependent T cell signaling. However, under some circumstances, LIME may mediate inhibitory signals.
Subcellular location: Cell membrane
Post transnational modification: Phosphorylated on tyrosines upon TCR activation and/or CD4 coreceptor stimulation, or upon BCR stimulation; which leads to the recruitment of SH2-containing proteins.
Tissue Specificity: Expressed in peripheral blood lymphocytes, lymphoid tissues, and liver. Present in T-cells and plasma cells, and in various hematopoietic cell lines (at protein level).
BioGrid: 120264. 4 interactions.
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