Anti-LARGE1 Monoclonal Antibody (Clone:LARGE-02)

Product code: 30-1504

Clone name : LARGE-02
Clonality : Monoclonal
Application : FACS, WB
Reactivity : Human

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0.1 mg
$433.00 

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Format : Purified
Amount : 0.1 mg
Isotype : Mouse IgG2b
Purification : Purified by protein-A affinity chromatography
Storage condition : Store at 2-8°C. Do not freeze.
Gene : LARGE1
Gene ID : 9215
Uniprot ID : O95461
Alternative Name : LARGE1, KIAA0609, LARGE
Immunogen Information : Recombinant fragment of human LARGE1 (amino acids 35-142)
LARGE1 serves as a glycosyltransferase which participates in glycosylation of the muscle membrane protein alpha-dystroglycan. Mutations of LARGE1 lead to hypoglycosylation of alpha-dystroglycan and cause congenital muscular dystrophy (MDC1D) associated with severe mental retardation. Altered alpha-dystroglycan glycosylation may also play a role in cancer, as hypoglycosylation of the protein and loss of laminin binding have been demonstrated in invasive carcinoma cells.
Subcellular location: Golgi apparatus membrane
Tissue Specificity: Ubiquitous. Highest expression in heart, brain and skeletal muscle.
BioGrid: 114649. 11 interactions.
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