Anti-Kinesin (heavy chain) Monoclonal Antibody (Clone:KN-03)

Product code: 30-1265

Clone name : KN-03
Clonality : Monoclonal
Application : ICC
Reactivity : Mouse, Human, Rat, Pig

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0.1 mg
$433.00 

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Format : Purified
Amount : 0.1 mg
Isotype : Mouse IgM
Purification : Purified by precipitation and chromatography
Storage condition : Store at 2-8°C. Do not freeze.
Gene : KIF11
Gene ID : 3832
Uniprot ID : P52732
Alternative Name : KIF11, EG5, KNSL1, TRIP5
Immunogen Information : Enriched fraction of porcine brain kinesin.
Kinesin belongs to the group of microtubule-associated motor proteins known to convert chemical energy released from nucleoside triphosphates (preferentially from ATP) into mechanical energy. Conventional kinesin, member of the kinesin superfamily comprising more than 100 proteins, is involved in the anterograde vesicle transport in neuronal cells. Kinesin purified from mammalian brain homogenates is a heterotetramer consisting of two heavy (120 to 130 kDa) and two light chains (60 to 70 kDa), resulting in a molecular mass about 400 kDa. Each heavy chain contains an N-terminal globular motordomain with both a microtubule-binding site and an ATPase active center, stalk region responsible for heavy chain dimerization and finally C-terminal globular tail domain, which is implicated in cargo binding. Light chains may have a regulatory function.
Subcellular location: Cytoplasm, Cytoplasm
Post transnational modification: A subset of this protein primarily localized at the spindle pole is phosphorylated by NEK6 during mitosis; phosphorylation is required for mitotic function.
BioGrid: 110030. 143 interactions.
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