Anti-IL-33 Monoclonal Antibody (Clone: ABM2B23)

Product code: 10-4012

Clone name : ABM2B23
Clonality : Monoclonal
Reactivity : Human
Conjugate : Unconjugated

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Size
Price
100 µg
$150.00 

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Shipping Info:

Order now and get it on Wednesday November 06, 2024

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Format : Purified
Amount : 100 µg
Isotype : Mouse IgG1, Kappa
Purification : Protein G Chromatography
Content : 100 µg in 200 µl PBS containing 0.05% BSA and 0.05% sodium azide. Sodium azide is highly toxic.
Storage condition : Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.
Gene : IL33
Gene ID : 90865
Uniprot ID : O95760
Alternative Name : Interleukin-33, Interleukin-1 family member 11 (IL-1F11), Nuclear factor from high endothelial venules (NF-HEV), C9orf26, IL1F11, NFHEV
Subcellular location: Nucleus, Chromosome, Cytoplasmic vesicle, Secreted
Post transnational modification: The full-length protein can be released from cells and is able to signal via the IL1RL1/ST2 receptor. However, proteolytic processing by CSTG/cathepsin G and ELANE/neutrophil elastase produces C-terminal peptides that are more active than the unprocessed full length protein. May also be proteolytically processed by calpains (PubMed:19596270). Proteolytic cleavage mediated by apoptotic caspases including CASP3 and CASP7 results in IL33 inactivation (PubMed:19559631). In vitro proteolytic cleavage by CASP1 was reported (PubMed:16286016) but could not be confirmed in vivo (PubMed:19465481) suggesting that IL33 is probably not a direct substrate for that caspase.
Tissue Specificity: Expressed at high level in high endothelial venules found in tonsils, Peyer patches and mesenteric lymph nodes. Almost undetectable in placenta.
BioGrid: 124776. 7 interactions.
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