PE Conjugated, Anti-Ikaros Monoclonal Antibody (Clone:4E9)
Figure 1: Intracellular staining of Ikaros in human peripheral blood leukocytes with anti-Ikaros (4E9) PE.
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| Amount : | 100 tests |
| Isotype : | Mouse IgG1 |
| Storage condition : | Store in the dark at 2-8°C. Do not freeze. Avoid prolonged exposure to light. |
Ikaros, also known as IKZF1 (Ikaros family zinc finger protein 1) is a hematopoietic-specific transcription factor involved in the regulation of lymphocyte development, together with other members of this family, such as Aiolos and Helios. Ikaros forms homo- and heterodimers with these proteins and functions predominantly in early hematopoietic development. Expression of Ikaros, Aiolos and Helios is restricted to cells of the hematopoietic system, whereas other family members, Eos and Pegassus, are more widely expressed. Disruption of Ikaros leads to T and B cell leukemias.
| Subcellular location: | Cytoplasm |
| Post transnational modification: | Polyubiquitinated. |
| Tissue Specificity: | Abundantly expressed in thymus, spleen and peripheral blood Leukocytes and lymph nodes. Lower expression in bone marrow and small intestine. |
| BioGrid: | 115604. 142 interactions. |
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