Anti-IgA Monoclonal Antibody (Clone:AD3) (Discontinued)
Figure 1: Immunohistochemistry staining of human colon (paraffin sections) with anti-IgA (clone AD3).
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| Format : | Purified |
| Amount : | 0.1 mg |
| Isotype : | Mouse IgG1 |
| Purification : | Purified by precipitation and chromatography |
| Storage condition : | Store at 2-8°C. Do not freeze. |
| Gene : | IGHA1 |
| Uniprot ID : | P01876 |
| Alternative Name : | Ig alpha-1 chain C region |
| Immunogen Information : | Purified human IgA. |
Immunoglobulin A (IgA) is the major immunoglobulin class in body secretions that protects against infections of the mucous membranes lining the mouth, airways, and digestive tract. Its serum concentration is approximately 0.2 g/l and biological survival (T1/2 in plasma) 6 days. Plasma IgA is predominantly monomeric (160 kDa) and of the IgA1 subclass, and is mostly produced in the bone marrow. Over half of IgA produced by the intestinal lamina propria plasmocytes is in oligomeric form and 35% of it is IgA2.
Immunohistochemistry Recommended dilution:10 µg/ml
Positive tissue: colon
For Research Use Only. Not for use in diagnostic/therapeutics procedures.
| Subcellular location: | Secreted, Cell membrane |
| Post transnational modification: | N- and O-glycosylated. N-glycan at Asn-144: Hex5HexNAc4. |
| Tissue Specificity: | Detected in skin (PubMed:8618013). In the cornea, it is detected in the epithelial basement membrane, the epithelial cells, and at a lower level in stromal cells (at protein level) (PubMed:25676728). Stratified squamous epithelia. Found in hemidesmosomes. Expressed in cornea, oral mucosa, esophagus, intestine, kidney collecting ducts, ureter, bladder, urethra and thymus but is absent in lung, blood vessels, skeletal muscle and nerves. |
| BioGrid: | 107704. 9 interactions. |
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