Anti-Human CD77 Antibody (Clone : 38.13)

Product code: 30-2548

Clone name : 38.13
Clonality : Monoclonal
Application : ICC, FACS , IHC(F)
Reactivity : Human

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0.1 mg
$398.00 

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Format : Purified
Amount : 0.1 mg
Isotype : Lewis Rat IgM
Purification : Purified by protein-A affinity chromatography
Content : 1 mg/ml
Formulation : Phosphate buffered saline (PBS) solution with 15 mM sodium azide
Storage condition : Store at 2-8°C. Do not freeze.
Alternative Name : globotriaosylceramide Gb3, Gal-alpha1-4Gal-beta1-4Glc-beta1-Cer, P blood group
Immunogen Information : Daudi cell line (Burkitt's lymphoma)
CD77 (globotriaosylceramide Gb3), also known as the Pk blood group antigen, BLA (Burkitt´s lymphoma associated antigen), or CTH (ceramide trihexoside) is a neutral glycosphingolipid composed of three carbohydrate molecules linked to a lipid moiety in the cell membrane (Gal-alpha1-4Gal-beta1-4Glc-beta1-Cer). It is expressed on germinal center B cells, Burkitt´s lymphoma cells, it can be induced on extrafolicular B cells and it is also found on endothelia and epithelia. CD77 may be involved in elimination of germinal center B cells that fail to produce high affinity antibodies, and serves also as receptor for shiga toxin and verotoxin.
Specificity : The rat monoclonal antibody 38.13 recognizes CD77 (globotriaosylceramide Gb3), a neutral glycosphingolipid expressed mainly on the surface of B cell populations, such as germinal center B cells and Burkitt´s lymphoma cells.
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