Anti-Human CD268 Antibody (Clone : 11C1)
Shipping Info:
For estimated delivery dates, please contact us at [email protected]
Format : | Purified |
Amount : | 0.1 mg |
Isotype : | Mouse IgG1 kappa |
Purification : | Purified by protein-A affinity chromatography |
Content : | 1 mg/ml Formulation : Phosphate buffered saline (PBS) solution with 15 mM sodium azide |
Storage condition : | Store at 2-8°C. Do not freeze. |
Gene : | TNFRSF13C |
Gene ID : | 115650 |
Alternative Name : | TNFRSF13C, BAFFR, CVID4, BAFF-R, BROMIX, prolixin,TNF receptor superfamily member 13C |
Immunogen Information : | human CD268-transfected murine L1.2 cells |
CD268 / BAFF R is a TNFR family receptor that binds the B-cell-activating factor (CD257 / BAFF). Splice variants of CD268 have been observed both in man and mouse. A naturally occurring mutation of CD268 in A/WySnJ mice is associated with low number of mature B cells, but with normal B cell precursors. The role of BAFF in B-cell survival and activation make CD268 a potential diagnostic reagent. It may be involved in survival of B-cell malignancies. Experimental administration of a CD268-Fc fusion protein suppresses antibody responses. In T cells the CD268 costimulates their activation and proliferation. Defects in CD268 cause the common variable immunodeficiency 4 (CVID4).
Specificity : The mouse monoclonal antibody 11C1 recognizes an extracellular epitope of CD268 / BAFF R (B cell-activating factor receptor), a 19 kDa type III transmembrane protein expressed on resting B cells and CD4-positive T cells, but down regulated after activation.
Specificity : The mouse monoclonal antibody 11C1 recognizes an extracellular epitope of CD268 / BAFF R (B cell-activating factor receptor), a 19 kDa type III transmembrane protein expressed on resting B cells and CD4-positive T cells, but down regulated after activation.
There are currently no product reviews
|