Anti-Human CD268 Antibody (Clone : 11C1)

Product code: 30-2603

Clone name : 11C1
Clonality : Monoclonal
Application : FACS , IHC(P), IHC(F)
Reactivity : Human

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0.1 mg
$424.00 

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Format : Purified
Amount : 0.1 mg
Isotype : Mouse IgG1 kappa
Purification : Purified by protein-A affinity chromatography
Content : 1 mg/ml
Formulation : Phosphate buffered saline (PBS) solution with 15 mM sodium azide
Storage condition : Store at 2-8°C. Do not freeze.
Gene : TNFRSF13C
Gene ID : 115650
Alternative Name : TNFRSF13C, BAFFR, CVID4, BAFF-R, BROMIX, prolixin,TNF receptor superfamily member 13C
Immunogen Information : human CD268-transfected murine L1.2 cells
CD268 / BAFF R is a TNFR family receptor that binds the B-cell-activating factor (CD257 / BAFF). Splice variants of CD268 have been observed both in man and mouse. A naturally occurring mutation of CD268 in A/WySnJ mice is associated with low number of mature B cells, but with normal B cell precursors. The role of BAFF in B-cell survival and activation make CD268 a potential diagnostic reagent. It may be involved in survival of B-cell malignancies. Experimental administration of a CD268-Fc fusion protein suppresses antibody responses. In T cells the CD268 costimulates their activation and proliferation. Defects in CD268 cause the common variable immunodeficiency 4 (CVID4).
Specificity : The mouse monoclonal antibody 11C1 recognizes an extracellular epitope of CD268 / BAFF R (B cell-activating factor receptor), a 19 kDa type III transmembrane protein expressed on resting B cells and CD4-positive T cells, but down regulated after activation.
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