Anti-Human CD245 Mab (Clone:DY12)
Figure 1: Flow cytometry surface staining pattern of human peripheral whole blood stained using anti-human CD245 (DY12) purified antibody (concentration in sample 1.67 μg/ml, GAM APC).
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| Format : | Purified |
| Amount : | 0.1 mg |
| Isotype : | Mouse IgG1 kappa |
| Purification : | Purified by protein-A affinity chromatography. |
| Content : | Formulation: Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide. Concentration : 1 mg/ml |
| Storage condition : | Store at 2-8°C. Do not freeze. |
| Alternative Name : | p220/240, DY12, DY35 |
| Immunogen Information : | human NK-type YT2C2 cells |
Specificity: The mouse monoclonal antibody DY12 recognizes an extracellular epitope of CD245, a transmembrane protein expressed mainly by peripheral blood lymphocytes, NK cells, monocytes, granulocytes and platelets.
CD245 is a 220-250 kDa transmembrane protein of unknown structure. It is expressed at lower level on resting blood lymphocytes, granulocytes, platelets, and thymocytes, and at high level on monocytes and on IL-2-dependent T cell lines. It is also expressed on Ewing sarcoma and osteosarcoma cell lines. CD245 seems to act as a costimulation molecule of T and NK cells.
Flow cytometry: Recommended dilution: 1-5 μg/ml.
For Research Use Only. Not for use in diagnostic/therapeutics procedures.
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