Anti-Human CD100 FITC MAb (Clone: 133-1C6)

Product code: 30-2849

Clone name : 133-1C6
Clonality : Monoclonal
Application : FACS
Reactivity : Human
Conjugate : FITC

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100 tests
$433.00 

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Amount : 100 tests
Isotype : Mouse IgM
Purification : Purified antibody is conjugated with fluorescein isothiocyanate (FITC) under optimum conditions and unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography.
Content : Stabilizing Tris buffered saline (TBS), pH 8.0, 15 mM sodium azide
Storage condition : Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.
Gene : SEMA4D, semaphorin 4D
Gene ID : 10507
Uniprot ID : Q92854
Alternative Name : COLL4, SEMA4D, semaphorin 4D
Immunogen Information : PHA stimulated human PBL

Specificity: The mouse monoclonal antibody 133-1C6 recognizes an extracellular epitope of CD100, an approximately 150 kDa (when reduced) semaphorin family member expressed mainly on lymphocytes, NK cells, monocytes/macrophages and granulocytes, but also on some non-hematopoietic cells.

CD100, also known as semaphorin 4D, is a homodimerizing type I transmembrane glycoprotein containing an extracellular semaphorin domain. It is expressed on most hematopoietic cells with the exception of immature bone marrow cells, erythrocytes and platelets. A 120 kDa soluble form is generated from the transmembrane form by proteolytic cascade following primary T and B cell activation. It seems CD100 acts through dampening CD72-mediated negative signaling. CD100 promotes angiogenesis, invasive growth, proliferation and anti-apoptosis of cancer cells in vitro. Higher expression levels of CD100 correlate with poor survival in soft tissue sarcoma patients.

Flow cytometry: The reagent is designed for analysis of human blood cells using 4 μl reagent / 100 μl of whole blood or 106 cells in a suspension. The content of a vial (0.4 ml) is sufficient for 100 tests.

For Research Use Only. Not for use in diagnostic/therapeutics procedures.

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