Anti-Hu CD86 Purified Low Endotoxin

Product code: 30-2752

Clone name : BU63
Clonality : Monoclonal
Application : FACS, IP, WB, IHC-Fr, FUNC
Reactivity : Human
Conjugate : Purified Low Endotoxin

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0.1 mg
$389.00 

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Amount : 0.1 mg
Purification : Purified by protein-A affinity chromatography.
Content : Concentration: 0.5 mg/ml
Storage Buffer: Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
Storage condition : Store at 2-8°C. Do not freeze.
Gene : CD86
Gene ID : 942
Uniprot ID : P42081
Alternative Name : CD86 molecule B7-2, FUN-1, LAB72
Immunogen Information : B-lymphoblastoid cell line ARH 77
CD80 (B7-1) and CD86 (B7-2) are ligands of T cell critical costimulatory molecule CD28 and of an inhibitory receptor CTLA-4 (CD152). The both B7 molecules are expressed on professional antigen-presenting cells and are essential for T cell activation, the both molecules can also substitute for each other in this process. The question what are the differences in CD80 and CD86 competency has not been fully elucidated yet; there are still conflicts in results about their respective roles in initiation or sustaining of the T cell immune response.
Specificity :The mouse monoclonal antibody BU63 reacts with an extracellular epitope of CD86 (B7-2), a 70 kDa type I transmembrane glycoprotein of immunoglobulin supergene family, expressed on professional antigen-presenting cells, such as dendritic cells, macrophages or activated B lymphocytes.

Functional application: The antibody BU63 blocks mixed lymphocyte reaction (MLR) and binding of soluble CTLA-4 (CD152)-mulg fusion protein to CD86 (B7-2).
Flow cytometry: Recommended dilution: 5 µg/ml.

For Research Use Only. Not for use in diagnostic/therapeutics procedures.

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