Anti-Hu CD58 Purified
Flow cytometry surface staining pattern of human peripheral whole blood stained using anti-human CD58 (MEM-63) purified antibody (concentration in sample 1,67 μg/ml, GAM APC).
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| Format : | Purified |
| Amount : | 0.1 mg |
| Isotype : | Mouse IgG1 |
| Purification : | Purified by protein-A affinity chromatography. |
| Content : | 1 mg/ml Formulation: Phosphate buffered saline (PBS), pH 8.8, 15 mM sodium azide |
| Storage condition : | Store at 2-8°C. Do not freeze. |
Formulation:Phosphate buffered saline (PBS), pH 8.8, 15 mM sodium azide Specificity :The antibody MEM-63 reacts with CD58 (LFA-3), a 40-70 kDa extracellular membrane glycoprotein distributed over many tissues, leukocytes, erythrocytes, endothelial cells, epithelial cells and fibroblasts. CD58 (LFA-3) is an immunoglobulin family adhession molecule expressed by both hematopoietic and non-hematopoietic cells (often on antigen presenting cells) and serving as ligand of CD2. This interaction is important for T cell-mediated immunity. CD58 is expressed in transmembrane form and in GPI-anchored form; the later is constitutively associated with protein kinases whereas the transmembrane form activates kinase activity upon triggering. CD58 is a powerful tool for detection of minimal residual disease in acute lymphocytic leukemia, and for evaluation of liver damage related with hepatitis B.
Flow cytometry: Recommended dilution: 1-4 µg/ml. Cold-induced transient opalescent turbidity may appear during the storage at 2 - 8°C. Bring the antibody to room temperature until the turbidity disappears, and mix well before the use.
For Research Use Only. Not for use in diagnostic/therapeutics procedures.
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